HIV-1 TRANSGENE EXPRESSION IN RATS CAUSES OXIDANT STRESS AND ALVEOLAR EPITHELIAL BARRIER DYSFUNCTION



KSI-301: antibody biopolymer conjugate in retinal disorders

KSI-301 is a new intravitreal anti-vascular endothelial growth factor (VEGF) antibody biopolymer conjugate under investigation for the treatment of age-related macular degeneration (AMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO).Preclinical and early clinical trials so far have shown promising results in retinal vascular disea

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Disturbed intracellular folate homeostasis impairs autophagic flux and increases hepatocytic lipid accumulation

Abstract Background Metabolic associated fatty liver disease (MAFLD), a prevalent liver disorder affecting one-third of the global population, encompasses a spectrum ranging from fatty liver to severe hepatic steatosis.Both genetic and lifestyle factors, particularly diet and nutrition, contribute to its etiology.Folate deficiency, a frequently enc

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